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Data sufficient to produce the clustering in Figs. Autism spectrum disorders ASDs are a heterogeneous group of behaviorally defined disorders and are associated with hundreds of rare genetic mutations and several environmental risk factors. Mouse models of specific risk factors have been successful in identifying molecular mechanisms associated with a given factor. However, comparisons among different models to elucidate underlying common pathways or to Gay nude Heilbronn clusters of biologically relevant disease subtypes have been complicated by different methodological approaches or different brain regions examined by the labs that developed each model. Here, we use a novel proteomic technique, quantitative multiplex co-immunoprecipitation or QMI, to make a series of identical measurements of a synaptic protein interaction network in seven different animal models.

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Below, we first focus our analysis on only significant ANC hits, then we perform inter-model comparisons using the entire data matrix to attempt to cluster models into biologically relevant groups.

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